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Today in Greece, more than 197,000 people are ill with Alzheimer’s disease, with the prospect this number to launch in 354,000 in 2050, according to the president of the Panhellenic Federation of Alzheimer’s Disease and Related Disorders, Professor M. Tsolaki (Neurologist, Psychologist, Theologist).

Considering the words that Hippocrates from Kos (460 – 377 BC), the father of medical science, said: “Our food is our medicine and our medicine is our food”, the philosophy of our company was formed based on the Mediterranean diet as our main approach to human health. With innovative steps in collaboration with the scientific community, our purpose is to offer a non-pharmaceutical and economical approach to Alzheimer’s patients.

MICOIL STUDY 2016 – 2019 Neurological and Neuropsychological evaluation

Title:

MICOIL – Randomized double clinical research to evaluate the effect of high phenolic, Chalkidiki early harvest extra virgin olive oil in patients with Mild Mental Disorder.

https://clinicaltrials.gov/ct2/show/NCT03362996

Participants:

Professor M. Tsolaki PhDc (1,2) E. Lazarou MSc (2), M. Kozori Bsc (2), N. Petridou (2), E. Tampaki (1), I. Lazarou (1), M. Karakota (2 ), I. Saoulidis (1), E. Melliou (3), P. Magiatis (3)

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(1) 1st Neurological Clinic of GUH AHEPA, Medical School, Department of Health Sciences, Aristotle University of Thessaloniki, Greece

(2) Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece

(3) Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy of the National Kapodistrian University of Athens, Greece.

Description:

The Greek Association of Alzheimer’s Disease and Related Disorders in exclusive collaboration with YANNI’S OLIVE GROVE has conducted the only global study – clinical research on human patients with early harvest extra virgin olive oil of Chalkidiki, regarding the approach of Mild Mental Disorder, which is leads to Alzheimer’s disease.

Patients are evaluated through multiple neuropsychological tests such as MMSE, FUCAS, etc.

Purpose:

The purpose of the MICOIL clinical trial is a non-pharmacological approach to the disease using a completely natural product, which has:

  1. Very high content of vitamin E, which has anti-aging properties and protects the human cells from oxidative stress and
  2. polyphenols, which are natural antioxidants

Results:

The results of this research will be published soon in an internationally recognized medical journal.

MICOIL STUDY 2016 – 2019 Biomarkers of the fibrinolytic system (**2nd Award in the 5th International Medical Olympiad)

Title:

MICOIL – Evaluation of the effect on biomarkers of the fibrinolytic system with high phenolic, Chalkidiki early harvest extra virgin olive oil in patients with Mild Mental Disorder and Alzheimer’s Disease biomarkers.

Participants:

  1. Tzekaki MSc (3), Professor M. Tsolaki PhDc (1,2), Professor A. Pantazaki PhDc (3), G. Geromichalos PhDc (1), Professor Z. Sinakos PhDc (1), E. Lazarou MSc ( 2), M. Kozori Bsc (2).

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(1) 1st Neurological Clinic of GUH AHEPA, Medical School, Department of Health Sciences, Aristotle University of Thessaloniki, Greece

(2) Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece

(3) School of Chemistry, Laboratory of Biochemistry, Aristotle University of Thessaloniki, Greece

Description:

The Greek Association of Alzheimer’s Disease and Related Disorders in exclusive collaboration with YANNI’S OLIVE GROVE has conducted the only global study – clinical research on human patients with early harvest extra virgin olive oil of Chalkidiki, regarding the approach of Mild Mental Disorder, which is leads to Alzheimer’s disease.

This study examines the effect of EVOO therapy on the fibrinolytic factors PAI-1 and a2-antiplasmin, on trademarks of AD, tau and Aβ amyloid fragments and on an oxidative stress biomarker, MDA in the serum of MCI patients aiming to be exploited as a future preventive therapy. This study has never applied before.

Purpose:

The purpose of the MICOIL clinical trial is a non-pharmacological approach to the disease using a completely natural product, which has:

  1. Very high content of vitamin E, which has anti-aging properties and protects the human cells from oxidative stress and
  2. polyphenols, which are natural antioxidants

Results:

The results of this research will be published soon in an internationally recognized medical journal.

MICOIL STUDY 2016 – 2019 Restoration of the neuroprotective protein BMI-1 levels

Title:

MICOIL – Restoration of BMI-1 levels after the administration of early harvest extra virgin olive oil as a therapeutic strategy against Alzheimer’s disease.

Participants:

  1. Tzekaki MSc (3), Professor M. Tsolaki PhDc (1,2), Professor A. Pantazaki PhDc (3), Angelos

Papaspyropoulos PhDc (3), E. Lazarou MSc (2), M. Kozori Bsc (2).

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(1) 1st Neurological Clinic of GUH AHEPA, Medical School, Department of Health Sciences, Aristotle University of Thessaloniki, Greece

(2) Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece

(3) School of Chemistry, Laboratory of Biochemistry, Aristotle University of Thessaloniki, Greece

Description:

The Greek Association of Alzheimer’s Disease and Related Disorders in exclusive collaboration with YANNI’S OLIVE GROVE has conducted the only global study – clinical research on human patients with early harvest extra virgin olive oil of Chalkidiki, regarding the approach of Mild Mental Disorder, which is leads to Alzheimer’s disease.

This study investigates the implication of the neuroprotective protein BMI-1 in AD and the possibility to reverse the onset of the disease through the administration of extra virgin olive oil (EVOO) in Mild Cognitive Impairment (MCI) patients.

Purpose:

The purpose of the MICOIL clinical trial is a non-pharmacological approach to the disease using a completely natural product, which has:

  1. Very high content of vitamin E, which has anti-aging properties and protects the human cells from oxidative stress and
  2. polyphenols, which are natural antioxidants

Results:

The results of this research will be published soon in an internationally recognized medical journal.

MICOIL STUDY EXTENTION 2020 – 2022 Neurological and Neuropsychological evaluation

Title:

MICOIL EXTENTION – Randomized double clinical research to evaluate the effect of high phenolic, Chalkidiki early harvest extra virgin olive oil in patients with Mild Mental Disorder.

Participants:

(1) 1st Neurological Clinic of GUH AHEPA, Medical School, Department of Health Sciences, Aristotle University of Thessaloniki, Greece

(2) PANHELLENIC INSTITUTE OF NEURODEGENERATIVE DISEASES, Thessaloniki, Greece

(3) Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece

(4) School of Chemistry, Laboratory of Biochemistry, Aristotle University of Thessaloniki, Greece

(5) KEDEK – LABORATORY OF NEURODEGENERATIVE DISEASES, Aristotle University of Thessaloniki, Greece

Description:

The Greek Association of Alzheimer’s Disease and Related Disorders in exclusive collaboration with YANNI’S OLIVE GROVE decided to extend the only global study – clinical research named MICOIL 2016 – 2019, on human patients with early harvest extra virgin olive oil of Chalkidiki in 2020 – 2022, regarding the approach of Mild Mental Disorder, which is leads to Alzheimer’s disease.

Patients are evaluated through multiple neuropsychological tests such as MMSE, FUCAS, etc.

Purpose:

The purpose of the MICOIL clinical trial is a non-pharmacological approach to the disease using a completely natural product, which has:

  1. Very high content of vitamin E, which has anti-aging properties and protects the human cells from oxidative stress and
  2. Very high content of vitamin K, which contributes to normal blood clotting and to the maintenance of normal bones
  3. High & source of Omega-3, Omega-6, Omega-9 fatty acids, which are very useful in human health
  4. High source of Unsaturated, which in a balanced diet contributes to the maintenance of normal blood cholesterol levels
  5. polyphenols, which are natural antioxidants

Results:

The results of this research will be published in an internationally recognized medical journal.

MICOIL STUDY EXTENTION 2020 – 2022 Microbiome biomarkers

Title:

MICOIL –  Investigation of biomarkers and mechanisms affected by the chronic supplementation of the early harvest extra virgin olive oil (EVOO) in Mild Cognitive Impairment (MCI) patients

Participants:

(1) 1st Neurological Clinic of GUH AHEPA, Medical School, Department of Health Sciences, Aristotle University of Thessaloniki, Greece

(2) PANHELLENIC INSTITUTE OF NEURODEGENERATIVE DISEASES, Thessaloniki, Greece

(3) Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece

(4) School of Chemistry, Laboratory of Biochemistry, Aristotle University of Thessaloniki, Greece

(5) KEDEK – LABORATORY OF NEURODEGENERATIVE DISEASES, Aristotle University of Thessaloniki, Greece

Description:

The Greek Association of Alzheimer’s Disease and Related Disorders in exclusive collaboration with YANNI’S OLIVE GROVE decided to extend the only global study – clinical research named MICOIL 2016 – 2019, on human patients with early harvest extra virgin olive oil of Chalkidiki in 2020 – 2022, regarding the approach of Mild Mental Disorder, which is leads to Alzheimer’s disease.

Through a wide spectrum of laboratory examinations, many patient’s factors like the oxidative stress, neuro-inflammatory markers and the microbiome biomarkers will be checked.

Purpose:

The research comprises the determination, in serum and CSF, of a wide spectrum of factors including the well-established Alzheimer’s disease (AD) hallmarks, the oxidative stress and neuro-inflammatory markers and the microbiome biomarkers before and after one-year early harvest EVOO administration, which includes:

  1. Very high content of vitamin E, which has anti-aging properties and protects the human cells from oxidative stress and
  2. Very high content of vitamin K, which contributes to normal blood clotting and to the maintenance of normal bones
  3. High & source of Omega-3, Omega-6, Omega-9 fatty acids, which are very useful in human health
  4. High source of Unsaturated, which in a balanced diet contributes to the maintenance of normal blood cholesterol levels
  5. polyphenols, which are natural antioxidants

Results:

The results of this research will be published in an internationally recognized medical journal.

MICOIL STUDY EXTENTION 2020 – 2022 Brain Development - Organoid System

Τίτλος:

MICOIL STUDY –  Development of an Alzheimer’s brain tissue 3D-culture model for the examination of effects of the early harvest Extra Virgin Olive Oil and its constituent’s.

Participants:

(1) 1st Neurological Clinic of GUH AHEPA, Medical School, Department of Health Sciences, Aristotle University of Thessaloniki, Greece

(2) PANHELLENIC INSTITUTE OF NEURODEGENERATIVE DISEASES, Thessaloniki, Greece

(3) Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece

(4) School of Chemistry, Laboratory of Biochemistry, Aristotle University of Thessaloniki, Greece

(5) KEDEK – LABORATORY OF NEURODEGENERATIVE DISEASES, Aristotle University of Thessaloniki, Greece

Description:

The Greek Association of Alzheimer’s Disease and Related Disorders in exclusive collaboration with YANNI’S OLIVE GROVE decided to extend the only global study – clinical research named MICOIL 2016 – 2019, on human patients with early harvest extra virgin olive oil of Chalkidiki in 2020 – 2022, regarding the approach of Mild Mental Disorder, which is leads to Alzheimer’s disease.

It is intend to develop for the first time in the world, an Alzheimer’s brain tissue 3D-culture model from primary tissue-derived organoids, originated from human biopsies for the examination of the effects of the early harvest Extra Virgin Olive Oil (EVOO) and its constituent’s.

Purpose:

The purpose of the MICOIL clinical trial is a non-pharmacological approach to the disease using a completely natural product, which has:

  1. Very high content of vitamin E, which has anti-aging properties and protects the human cells from oxidative stress and
  2. Very high content of vitamin K, which contributes to normal blood clotting and to the maintenance of normal bones
  3. High & source of Omega-3, Omega-6, Omega-9 fatty acids, which are very useful in human health
  4. High source of Unsaturated, which in a balanced diet contributes to the maintenance of normal blood cholesterol levels
  5. polyphenols, which are natural antioxidants

Results:

The results of this research will be published in an internationally recognized medical journal.

Βιβλιογραφία / Bibliography:

Papaspyropoulos, A., Tsolaki, M., Foroglou, N., & Pantazaki, A. A. (2020). Modeling and Targeting Alzheimer’s Disease With Organoids. In Frontiers in Pharmacology (Vol. 11). Frontiers Media S.A. https://doi.org/10.3389/fphar.2020.00396